analysis confirms identity and equal structural integrity of NeuClone's biosimilar and the reference product Stelara, in both primary amino acid sequence and 3-D folding (structure).
As an initial step in the drug discovery process, we purified the BPL from golden staph, grew crystals of the enzyme and determined its 3D structure using X-ray crystallography
means you really know what is going on.
Electrochemical analysis of metalloproteins, X-ray crystallography
, and molecular biology approaches are also covered.
The Two Braggs exhibition marks the centenary of the publication of research in 1913 by William Henry Bragg and his son William Lawrence which gave birth to the field of X-ray crystallography
- still a vital tool used today to discover new drugs to treat diseases.
Further, the AChBPs amenability to X-ray crystallography
has enabled us to provide more than 100 structures of the proteins in complex with numerous peptides, toxins, and therapeutically relevant compounds.
Although the father of X-ray crystallography
, Max von Laue, did not believe that it would be possible to determine atomic structures of enzymes with X-ray crystallography
, the first structures of proteins were determined at the end of the 50s and the beginning of the 60s of the last century [4, 5].
determines the 3D arrangement of atoms within a crystal by analyzing the diffraction pattern of X-rays that strike the study target.
Researchers have solved the challenging crystal structure of the leptin-binding domain of the obesity receptor using state of the art X-ray crystallography
, helping them to work out how to block or stimulate the receptor.
This review discusses the process of structure-based drug design, highlighting the problems surrounding the structural determination of biological targets by X-ray crystallography
. It also presents an effective solution enabling the crystallization process to be successfully incorporated into the automated drug discovery process.
The Takahashi laboratory has spent years determining the 3-D structure of the CLOCK:BMAL1 complex using x-ray crystallography
. The breakthrough came in the spring of 2011, when Yogarany Chelliah, a research specialist at the university, was able to crystallize the proteins.
The model predicted specific binding sites for C[O.sub.2], which were then confirmed experimentally by x-ray crystallography
. Amazingly, there was an almost perfect match.