(37) In both cases, the medications were efficacious: onset of relief with zolmitriptan
occurred within 45 minutes vs 35 minutes for rizatriptan.
Even more compelling evidence was provided by the second part of the study, in which patients were allowed to use zolmitriptan
to treat headaches of any intensity in open-label fashion for a full year.
A comparative trial of zolmitriptan
and sumatriptan for the acute oral treatment of migraine.
"If a patient can tolerate the triptans and wants fast onset of action with oral dosing, then zolmitriptan
and rizatriptan would be the first choices," Dr.
Those occurring less than 2% (asthenia, nausea, dizziness, paresthesias, and somnolence) were mild to moderate in severity and likely associated with zolmitriptan
By these criteria, rizatriptan was 26% more effective than zolmitriptan
, but this difference was not statistically significant (p = 0.075), Dr.
* STUDY DESIGN AND VALIDITY This randomized double-blinded placebo-controlled crossover study compared 5-mg and 10-mg doses of zolmitriptan
with placebo for the acute treatment of cluster headaches.
Poster Title: Concomitant Use of Serotonergic Drugs with Zolmitriptan
in a One-year Safety Trial
Table 1 Medications associated with serotonin syndrome Class Medication(s) Antidepressants Selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants Monoamine oxidase inhibitors Trazodone Mirtazapine Triptans Almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
Anxiolytics Buspirone Antiemetics Ondansetron, granisetron, metoclopramide Herbal supplements St.
Oral almotriptan and zolmitriptan
are also approved for use in children 12 to 17 years of age.
Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan
and sumatriptan in rat brain.
There are no human pregnancy data for zolmitriptan
(Zomig; Zomig-ZMT), but as with all triptans, there is a possible risk of preterm birth.